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Continuous-flow photochemical carbene transfer reactions .

Continuous-flow photochemical carbene transfer reactions .

Dec 20, 2019 · Photochemistry constitutes an important tool to conduct environmentally benign and efficient transformations in organic synthesis. Conventional batch transformations are limited in productivity and scale due to Beer's law, which can be easily overcome using flow chemistry approaches. Herein, we report on the continuous-flow photolysis of aryl diazoacetates using a glass microreactor .

Halogenation of organic compounds using continuous flow .

Halogenation of organic compounds using continuous flow .

Continuous flow chemistry offers unique opportunities to expand the array of synthetic methods available to the organic chemist. Chemistries and reagents classically "forbidden" under batch conditions, especially on a large scale due to safety reasons, become feasible using continuous flow and microreactor technology.

From p ‐Xylene to Ibuprofen in Flow . - Chemistry Europe

From p ‐Xylene to Ibuprofen in Flow . - Chemistry Europe

Jul 23, 2019 · Ibuprofen was prepared from an inactive and inexpensive p‐xylene by three‐step flow functionalizations through chemoselective metalations of benzyl positions in sequence using an in situ generated LICKOR‐type superbase.The flow approach in the microreactor facilitated the comprehensive exploration of over 100 conditions in the first‐step reaction by varying concentrations, temperatures .

A hybrid microreactor/microwave high-pressure flow system .

A hybrid microreactor/microwave high-pressure flow system .

Nov 01, 2013 · An actual photograph of the microreactor/microwave hybrid system of a novel design used in the present study is displayed in Fig. 1a; a schematic model of the whole system is illustrated in Fig. 1b. The two solutions were introduced into the microreactor (YMC Co. Ltd. Deneb; Helix type) at a fixed flow rate of 0.5 mL min −1 using a syringe driver pump, after which the mixture was continually .

Basics of Flow Microreactor Synthesis | Jun-ichi Yoshida .

Basics of Flow Microreactor Synthesis | Jun-ichi Yoshida .

"This monograph gives a nice introduction to the field of flow chemistry and represents definitely a must-have for most people that are new in the field. . the book is of great interest to students and to newcomers in the field and its low cost will make it a compulsory reading for this target group." (Timothy Noël, Angewandte Chemie International Edition, Vol. 54 (46), November, 2015)

Design and Fabrication of a High-Throughput Microreactor .

Design and Fabrication of a High-Throughput Microreactor .

Nov 27, 2012 · The effect of distributor and channel positions on flow uniformity in a high-throughput reactor is studied using a COMSOL MULTIPHYSICS, CFD package. The best design is subsequently fabricated and evaluated for propane total oxidation reaction at low conversions. Comparison of our design with a literature design is also presented. The results indicate that the conical distributor .

Microreactor. [Courtesy of S. K. Ajmera, M. W. Losey, K .

Microreactor. [Courtesy of S. K. Ajmera, M. W. Losey, K .

The entering partial pressure of A is 231 kPa (2.29 atm), and the entering flow to each microreactor is equimolar. The molar flow rate of CO is 2 × 10 −5 mol/s and the volumetric flow is 2.83 × 10 −7 m 3 /s. The weight of catalyst in one microreactor: W = 3.5 → 10 −6 kg. The reactor is kept isothermal at 120ºC.

Synthesis of mesoporous silica microspheres by a spray .

Synthesis of mesoporous silica microspheres by a spray .

Jun 01, 2020 · Inspired by the Stӧber method (Stӧber et al., 1968), herein, a surfactant-free carbonation method was proposed to synthesize silica spheres, in which the concentration of the silicate species was controlled to a similar level as the Stӧber method, promoting facile silica self-assembly.The representative SEM micrographs of the as-synthesized silica microspheres, at low and high .

Chemistry – A European Journal: Vol 25, No 60 - Chemistry .

Chemistry – A European Journal: Vol 25, No 60 - Chemistry .

A few‐millisecond chemistry approach, conducting a series of reactions with short‐lived intermediates in a flow microreactor, enabled chemical conversions involving alkyllithiums bearing an electrophilic functional group, which are virtually impossible with conventional macro batch reactors.Controlling such reactions are extremely difficult, because the functional groups readily react .

An Integrated Microreactor System for Self‐Optimization of .

An Integrated Microreactor System for Self‐Optimization of .

Timothy Noël, Yuanhai Su, Volker Hessel, Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis, Organometallic Flow Chemistry, 10.1007/3418_2015_152, (1-41), (2016).

Spurring Radical Reactions of Organic Halides with Tin .

Spurring Radical Reactions of Organic Halides with Tin .

Tributyltin hydride-mediated radical reactions of organic halides were successfully carried out in a continuous flow system using a microreactor. The reactions proceeded within a very short period of time, coupled with quickly decomposing radical initiators such as V-65 and V-70. The continuous flow reaction system was applied to gram scale synthesis of a key intermediate for furofuran lignans.

Basics of Flow Microreactor Synthesis | Jun-ichi Yoshida .

Basics of Flow Microreactor Synthesis | Jun-ichi Yoshida .

"This monograph gives a nice introduction to the field of flow chemistry and represents definitely a must-have for most people that are new in the field. . the book is of great interest to students and to newcomers in the field and its low cost will make it a compulsory reading for this target group." (Timothy Noël, Angewandte Chemie International Edition, Vol. 54 (46), November, 2015)

Microreactors in Organic Chemistry and Catalysis, Second .

Microreactors in Organic Chemistry and Catalysis, Second .

Figure 9.32 Process flow sheet for the microplant used for toluene sulfonation. Source: By courtesy of Elsevier [133]. The process flow sheet of the microreactor plant is shown in Figure 9.33 [133, 134]. Toluene is heated to 40 °C using a microstructured heat exchanger while, at the same time, liquid sulfur trioxide is vaporized by heating to .

The Mainstreaming of Continuous Flow API Synthesis .

The Mainstreaming of Continuous Flow API Synthesis .

Jul 02, 2014 · Flow chemistry is often considered as an option when exploring new chemical routes, increasing yield, lowering the cost of goods, and generating IP, according to Roberge. "One of the main drivers for the implementation of flow chemistry is, however, to perform a reaction that cannot be done with traditional batch production, such as those .

Nitro‐Substituted Aryl Lithium Compounds in Microreactor .

Nitro‐Substituted Aryl Lithium Compounds in Microreactor .

Aiichiro Nagaki, Eiji Takizawa and Jun‐ichi Yoshida, Generation and Reactions of Oxiranyllithiums by Use of a Flow Microreactor System, Chemistry – A European Journal, 16, 47, (14149-14158), (2010).

Flow Technology for the Genesis and Use of (Highly .

Flow Technology for the Genesis and Use of (Highly .

In the field of organic synthesis, the advent of flow chemistry and flow microreactor technology represented a tremendous novelty in the way of thinking and performing chemical reactions, opening the doors to poorly explored or even impossible transformations using batch methods. . Angewandte Chemie International Edition, 10.1002/anie .

Recent Advances in Continuous‐Flow . - Chemistry Europe

Recent Advances in Continuous‐Flow . - Chemistry Europe

Yi-Feng Wang, Zhen-Hui Jiang, Ming-Ming Chu, Suo-Suo Qi, Hao Yin, Hong-Te Han, Dan-Qian Xu, Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor, Organic & Biomolecular Chemistry, 10.1039/D0OB00588F, (2020).

Halogenation of organic compounds using continuous flow .

Halogenation of organic compounds using continuous flow .

Continuous flow chemistry offers unique opportunities to expand the array of synthetic methods available to the organic chemist. Chemistries and reagents classically "forbidden" under batch conditions, especially on a large scale due to safety reasons, become feasible using continuous flow and microreactor technology.

Evaluating the Potential for Continuous Chemical .

Evaluating the Potential for Continuous Chemical .

Apr 24, 2013 · Most early equipment for flow chemistry was designed for the laboratory. Chemical manufacturers and pharmaceutical companies, including DSM, have been working with microreactor manufacturers to address this issue, though, and pilot- and small commercial-scale equipment is becoming available, often by "numbering up" and running several .

link.springer.com

link.springer.com

Electrosynthesis offers a powerful tool for the formation of anion and cation radical intermediates and for driving clean synthetic reactions without the need for additional chemical reagents. Recent advances in microfluidic reactor technologies triggered an opportunity for new microflow electrolysis reactions to be developed for novel and clean electrosynthetic processes.

A hybrid microreactor/microwave high-pressure flow system .

A hybrid microreactor/microwave high-pressure flow system .

Nov 01, 2013 · An actual photograph of the microreactor/microwave hybrid system of a novel design used in the present study is displayed in Fig. 1a; a schematic model of the whole system is illustrated in Fig. 1b. The two solutions were introduced into the microreactor (YMC Co. Ltd. Deneb; Helix type) at a fixed flow rate of 0.5 mL min −1 using a syringe driver pump, after which the mixture was continually .

Microreactor Flow Synthesis of the Secondary High .

Microreactor Flow Synthesis of the Secondary High .

The secondary high explosive 2,6-diamino-3,5-dinitropyrazine-1-oxide, or LLM-105, has been synthesized using a commercially available flow microreactor system. Investigations focused on optimizing flow nitration conditions of the cost effective 2,6-diaminopyrazine-1-oxide (DAPO) in order to test the feasibility and viability of flow nitration as a means for the continuous synthesis of LLM-105.

A microreactor from the MIT group similar to the one sh .

A microreactor from the MIT group similar to the one sh .

A microreactor from the MIT group similar to the one shown in Figure P5-21 B was used to produce phosgene in the gas phase. We continue our discussion on micro reactors in Chapter 6. The microreactor is 20 mm long, in diameter, and packed with catalyst particles 35 pm in diameter. The entering partial pressure of A is 231 kPa (2.29 atm), and the entering flow to each microreactor is .

Continuous flow Buchwald–Hartwig amination of a .

Continuous flow Buchwald–Hartwig amination of a .

A flow process for direct amination of a pharmaceutically relevant substrate using a Pd-NHC based catalyst was demonstrated in a lab-scale mini-plant and in a pilot-scale plant. The lab-scale mini-plant was used to determine catalyst stability under recycling conditions. Results in the mini-plant have shown Celebrating the 150th anniversary of the German Chemical Society

Continuous flow Buchwald–Hartwig amination of a .

Continuous flow Buchwald–Hartwig amination of a .

A flow process for direct amination of a pharmaceutically relevant substrate using a Pd-NHC based catalyst was demonstrated in a lab-scale mini-plant and in a pilot-scale plant. The lab-scale mini-plant was used to determine catalyst stability under recycling conditions. Results in the mini-plant have shown Celebrating the 150th anniversary of the German Chemical Society

Chemistry – A European Journal: Vol 25, No 60 - Chemistry .

Chemistry – A European Journal: Vol 25, No 60 - Chemistry .

A few‐millisecond chemistry approach, conducting a series of reactions with short‐lived intermediates in a flow microreactor, enabled chemical conversions involving alkyllithiums bearing an electrophilic functional group, which are virtually impossible with conventional macro batch reactors.Controlling such reactions are extremely difficult, because the functional groups readily react .

Recent Advances in Continuous‐Flow . - Chemistry Europe

Recent Advances in Continuous‐Flow . - Chemistry Europe

Yi-Feng Wang, Zhen-Hui Jiang, Ming-Ming Chu, Suo-Suo Qi, Hao Yin, Hong-Te Han, Dan-Qian Xu, Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor, Organic & Biomolecular Chemistry, 10.1039/D0OB00588F, (2020).

Controlled polymerization and polymeric structures : flow .

Controlled polymerization and polymeric structures : flow .

COVID-19 Resources. Reliable information about the coronavirus (COVID-19) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this WorldCat.org search.OCLC's WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus .

Integrated CO 2 capture-fixation chemistry via interfacial .

Integrated CO 2 capture-fixation chemistry via interfacial .

Mar 06, 2017 · To immobilize DBU-ILs on the tips of cylindrical bundles of SiNWs via ultraviolet-initiated thiol-ene click chemistry 26, the -SH-modified SiNWs-PDMS microreactor was .

Generation and Reactions of Oxiranyllithiums by Use of a .

Generation and Reactions of Oxiranyllithiums by Use of a .

Oct 28, 2010 · Aiichiro Nagaki, Shigeyuki Yamada, Masatomo Doi, Yutaka Tomida, Naofumi Takabayashi and Jun-ichi Yoshida, Flow microreactor synthesis of disubstituted pyridines from dibromopyridines via Br/Li exchange without using cryogenic conditions, Green Chemistry, 10.1039/c0gc00852d, 13, 5, .